Clean-in-place systems for biotechnology and pharma
Ensure seamless transitions between production batches with efficient, high-performance cleaning systems tailored to maintain peak hygiene and operational precision in complex liquid formulation processes.

The Clean-In-Place Systems from BRS Biotech are designed to meet the stringent demands of the biotech, pharmaceutical, and food processing industries by ensuring meticulous cleaning of fermentors, vessels, and piping systems. These systems utilize a single-pass or multi-circuit operation with automatic control to manage temperature, time, and cycle, which facilitates efficient cleaning and preparation between production batches. Suitable for applications ranging from monoclonal antibodies and insulin production to sauces and plant-based milk formulations, these systems accommodate vessel volumes between 150 to 600 liters.
Constructed from SUS316L stainless steel, they offer superior corrosion resistance, essential for maintaining integrity in aggressive environments. Operating at a maximum temperature of 85°C and with a solution flow rate ranging from 10-25 m³/h, they meet various cleaning needs. Energy efficiency is enhanced through precise control systems, and the optional provision of GMP documentation ensures adherence to industry standards. Designed for seamless integration into existing production lines, they support both batch and automatic operations, offering flexibility and reliability for diverse production demands.
Benefits
- Enhances production efficiency by ensuring rapid and thorough equipment cleaning.
- Lowers operational costs with automatic control systems, minimizing manual intervention.
- Preserves product integrity through precise cleaning tailored to biopharmaceutical and food standards.
- Supports compliance with industry regulations with available GMP documentation.
- Increases equipment lifespan with corrosion-resistant SUS316L construction.
- Applications
- Sauces,Liquid formulations,Fine chemicals,Fermented products,Nutraceuticals,Biopharmaceuticals,Enzymes,Biofuel,Baby food,Plant-based milk,Pharmaceuticals
- End products
- Paracetamol,Ketchup,Ethanol,Lipase enzymes,Insulin,Infant formula,Monoclonal antibodies,Cough syrup,Almond milk,Omega-3 supplements,Yogurt
- Steps before
- Setup,Installation,Loading
- Steps after
- Sterilization,Product Changeover,Equipment Inspection
- Input ingredients
- Output ingredients
- Vessel volume
- 150-600 L
- Vessel material
- SUS316L
- Voltage
- 3×400 VAC,60 Hz
- Solution flow
- 10-25 m³/h
- Max temperature
- 85 °C
- Circuits
- Single-pass or multi-circuit
- Control
- Automatic control
- Cleaning method
- CIP / Automatic
- Automation level
- Automatic control
- Batch vs. continuous operation
- Single-pass or multi-circuit
- Control system
- Automatic solution return
- Temperature control
- Max temperature 85°C
- Energy source
- Voltage 3×400 VAC,60 Hz
- Corrosive resistance (e.g. acids)
- SUS316L
- Tank volume
- 150-600 L
- Tank material
- SUS316L
- Max temperature
- 85 °C
- Solution flow rate
- 10-25 m³/h
- Voltage
- 3×400 VAC,60 Hz
- Control type
- Automatic control
- Installation
- Swift and simple
- Installation type
- Swift and simple installation
- Maintenance requirement
- Easy maintenance and operation
- Market info