Pharmaceutical extrusion and spheronization system
Achieve precise control over pellet size and uniformity with this advanced system, perfect for developing controlled-release drug formulations and enhancing production efficiency in pharmaceutical processes.
The NICA Integrated Pelletizing System from GEA merges extrusion and spheronization technologies to create pharmaceutical-grade spherical pellets. Ideal for developing controlled-release tablets and pediatric formulations, this system operates across development to large-scale production. It features models like IPS5 and IPS200, with capacities ranging from 5 kg/h to 200 kg/h. Automated dosing ensures precise batch transfer, while the HMI interface allows for manual or automated control. Constructed for continuous operation, it integrates seamlessly into existing lines and reduces downtime via optional hot-swappable components. The modular system complies with GMP standards, supporting diverse pharmaceutical applications with customizable extruder and spheronizer configurations to meet specific process requirements.
Benefits
- Enhances production efficiency with continuous operation from small to large-scale outputs.
- Minimizes manual intervention through automated dosing and discharge systems.
- Adapts to diverse pellet formulations, supporting flexible pharmaceutical production.
- Ensures compliance with GMP standards for safe, high-quality output.
- Offers easy maintenance with hot-swappable spheronizer components, reducing downtime.
- Applications
- Pellets,Spherical pellets,Pharmaceutical products,Pharmaceuticals
- End products
- Multiparticulate drug delivery systems,Pediatric dosage forms,Microencapsulated active ingredients,Gastro-resistant pellets,Modified-release capsules,Taste-masked drug formulations,Controlled-release tablets,High-dose direct pellet formulations
- Steps before
- Formulation,Mixing,Granulation
- Steps after
- Drying,Coating,Tablet Pressing,Packaging
- Input ingredients
- wet mass,raw material
- Output ingredients
- spherical pellets,extrudate
- Production Capacity
- 5 kg/h to 200 kg/h
- Spheronizer Size
- S250,S450,S700
- Extruder Size
- E100,E140,E220
- Extrudate Distribution
- Manual / Actuated Dosing Plate / Actuated Shuttlebox
- Screen Hole Sizes
- Standard 0.6mm up to 1.5mm
- Pellet Size
- 50 g to full production scale
- Control System
- Manual / HMI / PLC
- Shperonizer Trolley Hot-swap
- Yes (IPS200)
- Batch Size for Manual Mode
- 400 g (IPS25)
- Batch Process vs. Continuous Process
- Continuous
- Automation
- Automatic / Manual Dosing
- Working Mechanism
- Extrusion and Spheronization
- Integrated Steps
- Continuous Production
- Batch vs. Continuous Operation
- Continuous
- Automation Level
- Manual / Automate via HMI/PLC
- Cleaning Method
- Manual / Assisted with Timer
- Changeover Time
- Hot-swap for Spheronizers
- CIP/SIP
- Not specified
- Energy efficiency
- Not specified
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Extruder size
- E100,E140,E220
- Spheronizer size
- S250,S450,S700
- Discharge method
- Manual / Actuated
- Jacketed Spheronizer Bowl
- IPS100,IPS200
- Compact footprint
- Yes
- Spheronizer Plate
- Standard Radial Single-Piece Plate
- Spheronizer trolley
- Hot-swap capability
- Control panel type
- HMI/PLC
- Integration with PharmaConnect® platform
- Yes
- Actuated dosing valve
- Available
- Spheronizer tooling
- Two-Piece with radial and parallel designs
- Jacketed spheroniser bowl
- Available in IPS100 and IPS200
- Spheronizer trolley “hot-swap”
- Available in IPS200
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.