Variable density pellets extruder and spheronizer
Develop diverse pellet densities for enhanced drug formulation with precise control over extrusion and spheronization, ensuring consistent texture and size, and optimizing active ingredient delivery in complex product matrices.
The Caleva Model VDE Benchtop Variable Density Extruder and Spheronizer Kit is designed for formulation development in pharmaceutical and nutraceutical applications. This innovative system allows for the production of pellets with varying densities through precise control of extruder screen hole depth, enhancing the quality and consistency of controlled-release and multiparticulate dosage forms. The kit includes a bench-top multi-bowl spheronizer with a 250 mm diameter bowl. Ideal for research laboratories and formulation development teams, it accommodates experimental and scale-up processes, providing flexibility with variable extrudate lengths from 1 to 12 mm. This integration ensures high uniformity in pellet size and shape, thereby optimizing drug loading and dissolution profiles. With energy-efficient operations and the ability to seamlessly integrate into existing lines, the equipment supports compliance with industry standards, offering customization options for specific project needs.
Benefits
- Enhances pellet consistency and uniformity, improving product quality and yield.
- Expands formulation flexibility by allowing precise control over pellet density.
- Boosts active ingredient loading, optimizing therapeutic efficacy.
- Accelerates development timelines with efficient scale-up and integration capabilities.
- Supports compliance with pharmaceutical industry standards, ensuring reliable and safe operations.
- Applications
- Supplements,Drug formulation development,Nutraceuticals,Pharmaceuticals tablets,Pharmaceuticals
- End products
- Multiparticulate dosage forms,Microencapsulated drug pellets,Fast-dissolving tablets,High-potency supplements,Effervescent tablets,Nutraceutical pellets,Controlled-release pellets
- Steps before
- Mixing,Formulation Development
- Steps after
- Spheronization,Coating,Drying,Tablet Pressing
- Input ingredients
- experimental formulation applications,pellet components,active materials,screen hole length variations
- Output ingredients
- pellets of variable density,smoother extrudate surfaces,consistent sphere roundness,uniform pellet size and shape,higher extrudate quality,higher usable yields
- Extruder screen hole length
- 1 to 12 mm
- Bowl diameter
- 250 mm
- Capacity
- 50–150 kg/h
- Density variation capability
- Variable by screen hole depth
- Extrudate density
- Function of hole length
- Spheronizer application
- Multi Bowl Spheronization
- Screen thickness
- 1mm to 12mm
- Working Mechanism
- Variable Density Extrusion
- Integrated Steps
- Extrusion and Spheronization
- Batch vs. Continuous Operation
- Batch
- Automation Level
- Manual / PLC
- Density Control
- Variable through screen thickness
- Quality Improvement
- Smoother extrudate surfaces
- Abrasion resistance
- Yes
- Biological compatibility
- Yes
- Cleanability
- High
- Corrosive resistance (e.g. acids)
- Yes
- Density/particle size
- Variable / 1-12 mm
- Pellet Size Consistency
- Uniform size and shape
- Pellet Porosity Modification
- Yes/No
- Pellet Dissolution Profile Modification
- Yes/No
- Drug Loading Capacity
- Increased in single dose
- ISO 9001
- Cert No. 1503
- Machine footprint
- Benchtop
- Extruder screen thickness
- 1mm to 12mm
- Bowl diameter
- 250 mm
- Extruder hole length
- 1–12 mm
- Die hole diameter
- 1–12 mm
- Die hole depth
- 1–12 mm
- Screen thickness
- 1–12 mm
- Spheronizer bowl diameter
- 250 mm
- Extruder screen configurations
- Axial
- Market info
- Caleva Process Solutions is known for manufacturing and supplying specialized equipment for pellet and extrudate production in the pharmaceutical, nutraceutical, chemical, and food industries, emphasizing innovative process solutions and customer-focused engineering.