Making Probiotics
Find innovative production technology for making probiotics and connect directly with world-leading specialists
The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.
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Enrich the LAB cultivation medium with magnesium and manganese
Lactic acid bacteria (LAB) are used in many food products, but this strain requires a complex nutrient environment to develop.
Add manganese sulfate or magnesium sulfate to your cultivation medium to boost the metabolic activity of LAB. The minerals also act against external oxygen radicals and provide anaerobic growth for the bacteria.
Preserve cell viability with cryoprotectants when using probiotics processing technology
Freeze-drying your bacteria converts the probiotics into dried powder. However, freezing at very low temperatures and dehydration under vacuum stress the cells.
A cryoprotectant increases the viability of the cells, but different materials achieve different levels of protection. An emerging technique combines trehalose, sodium ascorbate, and skim milk to register a cell survival rate of around 75%.
Higher pH stability makes Bifidobacterium more resistant to post-acidification
Probiotic strains may produce acidity, affecting the stability of the product. Probiotics processing technology such as refrigerators reduce the pH value of bacterial cells in a phenomenon known as post-acidification.
The Lactobacillus delbrueckii ssp. Bulgaricus (STLB) species demonstrates a high relative drop in pH levels. On the other hand, Bifidobacterium has a lower capacity for developing acids, making strains like the Bifidobacterium lactis more resistant to post-acidification.
Ensure probiotic concentrations in end products meet claim requirements
Different regions around the world have separate regulatory labeling requirements for probiotic products. Proprietary blends are permitted, but individual dietary ingredients within a proprietary blend should be listed in descending order by their Colony Forming Units (CFU).
Any benefits declared about the strains should be backed up by scientific evidence that the amounts provided in the product are consistent with the information supporting the claim.
Processing steps involved in probiotics making
Which probiotics technology do you need?
Lab-scale fermenter for simultaneous batch processing
In laboratory settings where multiple fermentation processes need t...
Industrial high-pressure homogenizer
In dairy, beverage, and pharmaceutical industries, ensuring product stability and prol...
Aseptic dosing system for heat-sensitive ingredients
When producing beverages or dairy products with delicate additives, ...
Aseptic dosing unit for sensitive ingredients
In the food and beverage industry, maintaining the efficacy of heat-sensitiv...
Semi-continuous freeze dryer with easy-loading
Freeze-drying is both a time- and energy-consuming process. In addition to ...
Vision inspection system for tablets and capsules
Pharmaceuticals and healthcare product manufacturers dealing with oral ...
Pharmaceutical formulation and mixing tanks
Preparation lines for formulating pharmaceuticals include fixed and mobile tan...
Automatic laboratory capsule filler
Innovators in the highly regulated and highly dynamic pharmaceutical market place need ...
Retort Pouch Packaging Machine
A wide variety of products that were previously canned are now able to be more economically p...
Automatic capsule filler for liquid solutions
Use of liquid filled hard capsules is increasingly popular with today’...
Tumbler sieve for classifying and dedusting granular materials
For the classification of delicate granular material, scr...
Scale up capsule filler
For higher production volumes of pharmaceutical capsules, speed, accuracy and reliability of producti...
Benchtop weight sorter for tablets & capsules
For laboratory pharmaceutical R&D work or use in clinical trials, a...
Flexible contained powder discharge into drums
Powdered products are handled every day in the pharmaceutical and bioproces...